Pharmacokinetic of Ceftriaxone in Septic ICU Patients
Status:
Unknown status
Trial end date:
2007-03-01
Target enrollment:
Participant gender:
Summary
Ceftriaxone pharmacokinetics variability in intensive care unit septic patients
In intensive care units, drug dosage is often based on study made on healthy volunteers or on
less severe patients.
However, pharmacokinetic alterations have been described for some drugs used in intensive
care units.
These alterations, consequences of alteration of volume of distribution, of protein
concentrations, of impaired hepatic and renal functions can result in accumulation with
toxicity or " under dosage " with inefficacity.
Ceftriaxone is an antibiotic often prescribed in intensive care unit. However, despite this
large utilisation, very few data is available on the pharmacokinetic in intensive care unit,
and optimal dosage is not known.
Our objective is to develop a population pharmacokinetics model of ceftriaxone in intensive
care unit patients with sepsis, severe sepsis and septic shock and to identify the " data "
explaining interindividual variability of each pharmacokinetics parameter.
Phase:
Phase 4
Details
Lead Sponsor:
Association Pour La Promotion A Tours De La Reanimation Medicale