Pharmacokinetic and Pharmacodynamic Evaluation of Doripenem in Critically Ill Trauma Patients
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
The study hypothesis is to measure how the drug doripenem is cleared from the body of
critically ill trauma patients. The investigators will measure blood drug concentrations and
calculate how much the drug distributes in the body and how fast it is removed from the body.
There is little information on how drugs are cleared in critically ill patients and the wrong
dose of a drug could make it ineffective. The investigators will use this information to
predict the most reasonable dose to treat infections effectively in these patients.