Pharmacokinetic and Pharmacodynamic Effects of Smoked and Vaporized Cannabis
Status:
Completed
Trial end date:
2017-01-17
Target enrollment:
Participant gender:
Summary
Few studies have been conducted to assess the pharmacokinetic and pharmacodynamic effects of
smoked and vaporized cannabis. Careful analysis of different cannabis administration methods
on these parameters is required to determine the level and duration of biological cannabinoid
exposure and associated subjective, cardiovascular and cognitive effects. In the present
study the investigators evaluated the detection of cannabinoids in whole blood, oral fluid,
and urine, as well as the acute pharmacodynamics associated with smoked and vaporized
cannabis among individuals who were not regular cannabis users. The outcomes of the study
will extend scientific knowledge about the behavioral pharmacology and toxicology of smoked
and vaporized cannabis administration and can inform policies regarding clinical, workplace
and roadside drug testing programs.