Pharmacokinetic and Pharmacodynamic Effects of Oral Cannabis
Status:
Completed
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
Few studies have been conducted to assess the pharmacokinetic and pharmacodynamic effects of
orally consumed intact cannabis (e.g., cannabis-containing brownies). Careful analysis of
oral cannabis dose effects on these parameters is required to determine the level and
duration of biological cannabinoid exposure and associated subjective, cardiovascular and
cognitive effects. In the present study we evaluated the detection of cannabinoids in oral
fluid, plasma, hair, and urine for up to 9 days following consumption of oral cannabis (10mg,
25mg, or 50mg THC). The outcomes of the study will extend scientific knowledge about the
behavioral pharmacology and toxicology of oral cannabis administration and can inform
policies regarding clinical, workplace and roadside drug testing programs.
Phase:
Phase 1
Details
Lead Sponsor:
Johns Hopkins University
Collaborators:
RTI International Substance Abuse and Mental Health Services Administration (SAMHSA)