Pharmacokinetic and Dose Response Study of Asfotase Alfa in Adult Patients With Pediatric-Onset Hypophosphatasia (HPP)

• Status: Completed
• Trial end date: 2017-06-21
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of asfotase alfa in adult participants with pediatric-onset HPP.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Alexion Pharmaceuticals
• Treatments: Immunoglobulin G

Criteria

Inclusion Criteria:

1. Participants or their legal representative(s) provided written informed consent prior to undergoing any study-related procedures.

2. Participants were ≥18 years of age at Screening.

3. Participant had pediatric-onset hypophosphatasia (HPP), defined as onset of first sign(s)/symptom (s) of HPP prior to 18 years of age.

4. Participants had a documented diagnosis of HPP as indicated by a documented history of HPP-related skeletal abnormalities and 1 or more of the following:

• Documented tissue-nonspecific alkaline phosphatase (TNSALP) gene mutation(s) from a certified laboratory.

• Serum alkaline phosphatase (ALP) level below the age-adjusted normal range AND plasma pyridoxal-5'-phosphate (PLP) above the upper limit of normal at Screening.

5. Participants had a plasma inorganic pyrophosphate (PPi) level of ≥3.9 micromolar (µM) at Screening.

6. Female participants of childbearing potential had a negative pregnancy test at the time of enrollment.

7. Sexually active male and female participants of childbearing potential agreed to use a highly effective method of birth control during the study.

8. Female participants not of child-bearing potential due to sterilization (at least 6 weeks after surgical bilateral oophorectomy with or without hysterectomy or at least 6 weeks after tubal ligation) confirmed by medical history, or menopause.

9. Participants were willing to comply with study procedures and the visit schedule.

Exclusion Criteria:

1. Investigational site personnel directly affiliated with this study and/or their immediate families. Immediate family was defined as a spouse, parent, child, or sibling, whether biological or legally adopted.

2. Employees of Alexion Pharmaceuticals.

3. Currently enrolled in a clinical study involving another study drug or non-approved use of a drug or device.

4. Participated, within the last 30 days, in a clinical study involving a study drug (other than the study drug used in this study).

5. Completed or withdrawn from this study or any other study investigating asfotase alfa in the previous 3 years.

6. Women who were pregnant, planning to become pregnant, or breastfeeding.

7. Serum 25-hydroxy Vitamin D levels below 20 nanogram (ng) per milliliter (mL) at Screening.

8. Screening serum creatinine or parathyroid hormone (PTH) levels ≥1.5 times the upper limit of normal.

9. Any medical condition, serious concurrent illness and/or injury, recent orthopedic surgery, or other extenuating circumstance that, in the opinion of the Investigator, may have significantly interfered with study compliance or study endpoints.

10. Prior treatment with bisphosphonates within 2 years of study entry for any length of time or for more than 2 consecutive years at any prior timepoint.

11. Treatment with PTH, strontium, or sclerostin inhibitors within 6 months prior to the first dose of study drug.

12. Unwilling or unable to comply with the use of a data collection device on which study participants directly recorded data.