Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of Cytochromes

• Status: Completed
• Trial end date: 1969-12-31

Summary

The purpose of this study is to assess whether a cocktail of seven approved drugs (so-called "Basel cocktail") can be used for simultaneous phenotyping of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4.

• Phase: Phase 1

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Treatments: Caffeine; Chlorzoxazone; Efavirenz; Losartan; Metoprolol; Midazolam; Omeprazole