Pharmacokinetic Study of Oseltamivir and Intravenous Zanamivir in Healthy Adults
Status:
Completed
Trial end date:
2009-10-01
Target enrollment:
Participant gender:
Summary
Due in part to widespread availability of oseltamivir and clinical experience using
oseltamivir to treat H5N1 influenza virus infections, many strains of influenza have become
resistant to it. Other reliable methods of treating H5N1 must be identified in case of a
pandemic. One such option is intravenous zanamivir used in combination with oseltamivir. The
primary purpose of this study is to evaluate the interaction between oral oseltamivir and
intravenous zanamivir administered as either a continuous or intermittent infusion in healthy
adults.
Phase:
Phase 1
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)