This is a randomized, single center, open label, single dose, four way crossover study in
fasted healthy male subjects to compare the pharmacokinetics of nicotine following
administration of 3 prototype 4mg nicotine lozenge to an internationally marketed 4mg
nicotine lozenge. Blood samples will be drawn at pre-specified intervals for a total of 12
hours post dose in each treatment session and plasma samples analyzed for nicotine levels.