Overview

Pharmacokinetic (PK) and Pharmacodynamic (PD) Modeling of Ampicillin and Gentamicin in Peripartum Patients

Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
0
Participant gender:
Female
Summary
This study proposes to compare the metabolism of Ampicillin and Gentamicin by pregnant women to that of non-pregnant women; the placental transfer over time; and the subsequent metabolism of the transferred drug(s) in the neonate.
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Stanford University
Collaborator:
David Drover, MD
Treatments:
Ampicillin
Gentamicins
Criteria
Inclusion Criteria:

- Generally healthy, pregnant woman (28-42 weeks)

- Generally healthy, non-pregnant female

- Scheduled to receive Ampicillin and/or Gentamicin IV

- Ages 18-55 years old

- Relatively normal Comprehensive Metabolic Panel (if available), as evidenced by recent
blood work

- Able and willing to sign consent

Exclusion Criteria:

- Women with known renal or hepatic impairment; preeclampsia; Diabetes, including
Gestational; any medical condition that, in the opinion of the Investigator or
research team member, could potentially interfere with the study objectives

- Women who are participating in another study

- Pregnant with multiples

- BMI > 40