Pharmacokinetic Interactions Between Antiretroviral Agents and Antimalarial Drug Combinations
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to determine in healthy volunteers whether certain anti-HIV
medications (lopinavir/ritonavir and efavirenz) affect the drug levels of certain
anti-malarial medications (artesunate/ amodiaquine and artemether/ lumefantrine) and vice
versa. Since these drugs are degraded using overlapping pathways in the liver, it is
predicted that changes in both drug level and overall drug exposure will be observed.