Pharmacogenomics in Pulmonary Arterial Hypertension
Status:
Unknown status
Trial end date:
2013-07-01
Target enrollment:
Participant gender:
Summary
Our goal is to determine clinically in Pulmonary Arterial Hypertension patients if
associations exist between the efficacy and toxicity of sitaxsentan, bosentan, and
ambrisentan and several gene polymorphisms in several key disease-specific and therapy
specific genes. Also characterized is the relationship between these polymorphisms and the
severity of Pulmonary Arterial Hypertension using either baseline hemodynamic or clinical
surrogates for disease severity.
Hypothesis: Polymorphisms influence the efficacy and toxicity of specific Pulmonary Arterial
Hypertension therapy as well as development/severity of PAH via their effect on PA
remodeling, drug response, or metabolism.
This study requires a one time 8.5 ml blood sample and clinical data to be obtained at
initiation of therapy, 4 months after initiation of therapy and 12 months after initiation of
therapy.
Details
Lead Sponsor:
West Penn Allegheny Health System
Collaborators:
Bay Area Chest Physicians Baylor College of Medicine Chest Medical Associates Children's Hospital Colorado Columbia University Duke University Emory University Johns Hopkins University Latter Day Saints Hospital London Health Sciences Centre Louisiana State University Health Sciences Center in New Orleans Lung Diagnostics, Ltd. Massachusetts General Hospital Mayo Clinic Medical College of Wisconsin National Institutes of Health (NIH) Ohio State University Sentara Norfolk General Hospital Sir Mortimer B. Davis - Jewish General Hospital Southeastern Lung Care Suncoast Lung Center The University of Texas Medical Branch, Galveston Tufts Medical Center University Hospitals Cleveland Medical Center University of Alabama at Birmingham University of Calgary University of California, Los Angeles University of California, San Francisco University of Chicago University of Colorado, Denver University of Maryland University of Maryland, College Park University of Michigan University of Pittsburgh University of Southern California University of Texas Southwestern Medical Center Vanderbilt University Vanderbilt University Medical Center Washington University School of Medicine Wayne State University