1. The polycystic ovary syndrome is the major cause of infertility in the United States.
Metformin has been shown to increase frequency of ovulations in PCOS, and is used in
clinical practice to treat infertility, but some women with PCOS do not respond to
metformin treatment.
2. Knowing that a specific gene predicts the effect of metformin on ovulation would
facilitate more efficient and effective treatment of infertility in PCOS.
Phase:
N/A
Details
Lead Sponsor:
Virginia Commonwealth University
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)