Pharmacogenetics of Alcohol: Treatment Implications
Status:
Completed
Trial end date:
2011-07-01
Target enrollment:
Participant gender:
Summary
This study will explore the hypothesis that effects of alcohol are in part mediated by
increased production of neuroactive steroids, which interact with GABAA-receptors. We propose
to study non-dependent drinkers using a 4-session within-subjects design in which alcohol /
placebo is paired with dutasteride / placebo pretreatment. Dutasteride is a 5-alpha steroid
reductase (5AR) inhibitor that limits the production of dihydrotestosterone and the
5a-reduced neuroactive steroids allopregnanolone, pregnanolone and 3a,5a-androstanediol.
Phase:
N/A
Details
Lead Sponsor:
UConn Health
Collaborators:
National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health (NIH)