Pharmacogenetics of Ace Inhibitor-Associated Angioedema
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
The investigators would like to find out if sitagliptin (dipeptidyl peptidase-4 or DPP4
inhibition), a drug to treat diabetes, affects blood vessel relaxation in healthy people
receiving enalapril (angiotensin converting enzyme or ACE inhibition), a blood pressure
medicine. Understanding how these drugs interact in healthy people will help us learn their
potential effects in people who have diabetes.
Phase:
N/A
Details
Lead Sponsor:
Vanderbilt University
Treatments:
Angiotensin-Converting Enzyme Inhibitors Bradykinin Dipeptidyl-Peptidase IV Inhibitors Enalapril Enalaprilat Glucagon Glucagon-Like Peptide 1 Kininogens Natriuretic Peptide, Brain Neurokinin A Sitagliptin Phosphate Substance P