Overview

Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse

Status:
Completed
Trial end date:
2017-10-01
Target enrollment:
0
Participant gender:
All
Summary
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies suggest that medications affecting the noradrenergic system can reduce cocaine craving and use. The investigators will study the effect of doxazosin, an alpha-1 adrenergic antagonist, in reducing cocaine use and anxiety symptoms among cocaine-dependent individuals. In addition, the investigators will identify genetic subpopulations of participants who preferentially respond to the medication.
Phase:
Phase 2
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
VA Office of Research and Development
Collaborator:
Baylor College of Medicine
Treatments:
Adrenergic alpha-1 Receptor Antagonists
Cocaine
Doxazosin
Molecular Mechanisms of Pharmacological Action
Criteria
Inclusion Criteria:

1. Signed informed consent form and HIPAA authorization form

2. Subject is cooperative, understands the risks and benefits, and is willing and able to
adhere to study requirements

3. Any race or ethnic origin

4. Diagnosis of cocaine-dependence according to DSM-IV criteria

5. Between the ages of 18 and 64

6. Must be current users of cocaine with self-reported use of cocaine within the last 90
days, or at least one cocaine-positive urine during screening.

7. Women of childbearing age are eligible to be included in the study if they have a
negative pregnancy test at screening, agree to adequate contraception to prevent
pregnancy, to have monthly pregnancy tests, and they understand the risk of fetal
toxicity due to medication.

8. Must be in good general health as determined by self-report and/or CPRS-based medical
history, general clinical examination conducted by a study physician, and lab tests.
HIV testing will be recommended but is not required for participation in this study.

9. Motivated to discontinue or reduce cocaine use during the period of the study, as
evidenced both by the judgment of the Investigator or designee and by the subject's
compliance level with the requirement for attendance at clinic visits, such that
weekly urine sample requirements for inclusion criteria are fully met.

Exclusion Criteria:

1. Current diagnosis of other drug dependence, especially alcohol or benzodiazepine
dependence, or abuse (other than cocaine, tobacco, or cannabis)

2. Significant medical conditions (e.g., major cardiovascular, renal, endocrine, hepatic
disorders) such as abnormal liver function (with laboratory findings of SGOT or SGPT
greater than three times normal), hypotension, a current cardiac condition that in the
opinion of the investigator would contraindicate Doxasozin treatment, and those having
a high risk of cardiovascular disease, seizure disorders, or another significant
underlying medical condition which would contraindicate Doxazosin treatment

3. Lifetime schizophrenia, bipolar disorder, or other psychotic disorders (excluding
substance-induced psychotic disorders)

4. Actively considering plans of suicidality or homicidality

5. Women planning to become pregnant or breastfeed during the study, refusal to use a
reliable form of birth control, or refusal of monthly pregnancy testing

6. Subjects who are prescribed certain anti-hypertension drugs (i.e. doxasozin) will be
excluded because these medications may interact with Doxazosin's brain effects in
reducing cocaine abuse

7. Subject has participated in another clinical trial or received any other
investigational compound within 7 days prior to being randomized into this study