Pharmacogenetic Study of Different Hormone Therapies in Recent Menopause Women
Status:
Completed
Trial end date:
2011-04-01
Target enrollment:
Participant gender:
Summary
This is cross-over, randomized clinical trial, with objective to evaluate the effects of
low-dose oral hormone therapy and non-oral hormone therapy on endothelial function markers
(fibrinogen, von Willebrand factor, c-reactive protein), natriuretic peptide and on
anthropometric, metabolic and hormonal variables in early and healthy postmenopausal women
and analyzing polymorphisms in the estrogen receptor gene and FTO polymorphisms
Patients will be randomized to receive oral hormone treatment or non-oral hormone treatment
The investigators hypothesis is that a different genotypes in the receptor estrogen gene and
FTO may have an influences on treatment response in metabolic markers and cardiovascular risk
Phase:
N/A
Details
Lead Sponsor:
Denusa Wiltgen
Collaborators:
Conselho Nacional de Desenvolvimento Científico e Tecnológico Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Hospital de Clinicas de Porto Alegre