Pharmacogenetic Prediction of Metoprolol Effectiveness

• Status: Terminated
• Trial end date: 2017-08-23
• Target enrollment: 0
• Participant gender: All

Summary

The investigators will prospectively follow a population of patients with uncontrolled high blood pressure beginning metoprolol succinate therapy to determine the drug effect in an observational clinical trial. The investigators will determine each individual's genotype for both CYP2D6 and Adrenoceptor Beta 1 (ADRB1). Metabolomic markers will be identified to determine if specific metabolites are associated with drug response. The investigators' overall objective is to determine if genetics predicts metoprolol succinate response better than clinical factors such as age, race, body mass index, dose, and medication co-ingestion.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Colorado, Denver
• Collaborator: National Institute of General Medical Sciences (NIGMS)
• Treatments: Dextromethorphan; Metoprolol

Criteria

Inclusion Criteria:

1. Subjects between age >30 years and < 80 years

2. Subjects have diagnosis of uncontrolled essential hypertension.

Exclusion Criteria:

1. end stage liver disease,

2. end stage renal disease,

3. pregnant females,

4. American Society of Anesthesiologists (ASA) classification of >3,

5. wards of the state, prisoners,

6. decisionally challenged,

7. HR<60 bpm,

8. AV block>240 msec,

9. active reactive airway disease,

10. illicit drug abuse in the preceding 30 days,

11. hypersensitivity to metoprolol or its derivatives

12. severe peripheral arterial circulatory disorders.

Subjects will have a screening physical exam performed by Dr. Monte prior to enrollment in the study.