Overview

Pharmacodynamic Study to Assess the Effects of Repeated Dosing of SAR247799 on Endothelial Function in Patients With Type 2 Diabetes Mellitus

Status:
Completed

Trial end date:
2018-12-22

Target enrollment:

Participant gender:

Summary

Primary Objective: To assess the pharmacodynamic effects of SAR247799 on macrovascular endothelial function of the brachial artery using flow-mediated dilation (FMD) in patients with type 2 diabetes mellitus (T2DM). Secondary Objective: - To assess the pharmacodynamic effects of SAR247799 on microvascular endothelial function using laser Doppler perfusion monitoring in patients with T2DM. - To assess the safety profile of SAR247799 in patients with T2DM. - To assess the plasma pharmacokinetic profile of SAR247799 in patients with T2DM.

Phase:

Phase 1

Details

Lead Sponsor:

Sanofi

Treatments:

Acetylcholine
Sildenafil Citrate