Phamacological Reversal of Airway Instability During Sedation
Status:
Completed
Trial end date:
2011-08-01
Target enrollment:
Participant gender:
Summary
The investigators are attempting to demonstrate a decrease in the frequency and severity of
sedation-induced respiratory arrhythmias(central and obstructive apneas) with pharmacological
pre-treatment in this pilot project and then eventually to understand the mechanisms behind
this decrease. The efficacy and mechanisms of these treatments, while evaluated during sleep
in Obstructed Sleep Apnea (OSA) patients, have not been systematically studied during
sedation in either normal subjects or OSA patients. The agent to be assessed in this study in
physostigmine versus placebo.