Overview

Ph II Erlotinib + Sirolimus for Pts w Recurrent Malignant Glioma Multiforme

Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
Primary objective: To determine the 6-month progression free survival of patients with recurrent glioblastoma multiforme (GBM) treated with Erlotinib plus Sirolimus. Secondary objectives: To further define the safety and tolerability of Erlotinib plus Sirolimus when administered to patients with recurrent GBM; and to evaluate progression free survival, radiographic response and overall survival of patients with recurrent GBM treated with Erlotinib plus Sirolimus.
Phase:
Phase 2
Details
Lead Sponsor:
Duke University
Collaborators:
Genentech, Inc.
OSI Pharmaceuticals
Treatments:
Erlotinib Hydrochloride
Everolimus
Sirolimus