Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma
Status:
Withdrawn
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to determine the maximum tolerated dose (MTD) and dose
limiting toxicity (DLT) of dasatinib when combined with protracted, daily temozolomide (TMZ).
Secondary objectives are: To further evaluate the safety and tolerability of dasatinib plus
protracted, daily TMZ; 2. To evaluate the pharmacokinetics of dasatinib when administered
with protracted, daily TMZ among recurrent malignant glioma patients who are on and not on
CYP-3A enzyme inducing anti-epileptic drugs (EIAEDs); 3. To evaluate for anti-tumor activity
with this regimen in this patient population.