The study objectives are to investigate the toxicity and the BUMEL response rate; in patients
who reach the CR after autotransplantation, investigate if negativization of IF, influences
in disease evolution; in patients in PR after autotransplantation, analyze if the second
intensive procedure is capable of increasing the response rate and increasing the survival so
that patients who reached the CR with the first transplantation; Patients with MM primarily
resistant to the chemotherapy, investigate the efficacy of a double transplantation; patients
submitted to double transplantation, control the efficacy of the second transplantation in
front of allogenic transplantation.