Personalized Treatments for Depressive Symptoms in Patients With Advanced Heart Failure

• Status: Active, not recruiting
• Trial end date: 2022-04-01
• Target enrollment: 0
• Participant gender: All

Summary

We are doing this study to help patients, caregivers, and providers make decisions about how best to manage depressive symptoms in advanced heart failure. There are two evidence-based treatment approaches to treating depression in patients with advanced heart failure, behavioral action psychotherapy and treatment with anti-depressant medications. In this study we want to compare the effectiveness of these two treatment options to learn which treatment works better.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cedars-Sinai Medical Center
• Collaborator: Patient-Centered Outcomes Research Institute

Criteria

Inclusion Criteria:

1. HF New York Heart Association classes: II-IV.

2. Life expectancy of more than 6 months.

3. PHQ-9 score ≥10.

4. Diagnosis of Major Depressive Disorder, Persistent Depressive Disorder (Dysthymia), and Depressive Disorder Unspecified, as confirmed by the MINI 7.02.

Exclusion Criteria:

1. Imminent danger to self or others.

2. Cognitive impairments with a MOCA score of < 23.

3. Bipolar, Psychotic, and Substance-induced Disorders.

4. Patients in active treatment of depression who are already on antidepressants, psychotherapy, or both.