A prospective cohort of patients scheduled to undergo deep brain stimulation (DBS)
implantation surgery for the treatment of Parkinson's disease as per standard of care will be
invited to participate in this study. This mechanistic study is aimed at better understanding
the role of basal ganglia beta band (11-35 Hz) oscillations and resonance in the
manifestation of Parkinson's disease (PD) motor signs using closed-loop electrical
neurostimulation, levodopa medication, and computational modeling. The ultimate goal of this
study is to inform the development of closed-loop neuromodulation technology that can be
programmed and adjusted in real time based on patient-specific neural activity.