Persistent Postpartum Hypertension Pilot Trial

• Status: Recruiting
• Trial end date: 2022-05-30
• Target enrollment: 0
• Participant gender: Female

Summary

This study is a pilot, open-label, randomized controlled trial of postpartum women with hypertensive disorders pregnancy and persistent non-severe blood pressure. The purpose of the study to provide data that may provide guidance regarding blood pressure management of patients with non-severe postpartum hypertension. There are limited guidelines for best practice with persistent, non-severe hypertension, and treatment in this situation is usually at the provider's discretion.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Treatments: Antihypertensive Agents; Nifedipine

Criteria

Inclusion Criteria:

• Antepartum diagnosis of gestational hypertension

• preeclampsia

• superimposed preeclampsia without antepartum chronic hypertension medication

• Delivery at 23 weeks or greater

• Persistent elevation in BP >24 hours postpartum (>140/90 mm Hg) (2 or more BP >4 hours apart)

• 18 years or older

• English speaking

Exclusion Criteria:

• Need for continuation of antepartum antihypertensive medication

• Contraindication of calcium channel blocker use

• Severe range (160/110 mm Hg) blood pressure requiring treatment >24 hours after delivery

• Requires a 2nd oral antihypertensive medication for blood pressure control inpatient

• Acute cardiomyopathy or heart failure

• Creatinine ≥1.5

• Blood pressure <90/60 within 24 hours of discharge