Permeability MRI in Cerebral Cavernous Malformations Type 1 in New Mexico: Effects of Statins
Status:
Completed
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
Cerebral cavernous malformations (CCMs) are clusters of abnormal blood vessels in the brain
and spine. CCMs can bleed and cause strokes, seizures, and headaches. In some patients, CCMs
affect the blood brain barrier (BBB). The BBB is the body's separation of blood and its
contents in the brain from the brain tissue itself. Abnormal leakiness or permeability of
this barrier can cause disease. We will measure the permeability (leakiness) of the BBB using
a magnetic resonance imaging (MRI) technique called dynamic contrast-enhanced MRI (DCEMRI).
The purpose of this study is to look at whether statin medications change the permeability
(leakiness) of the blood brain barrier in CCM patients. Statin medications are used to lower
cholesterol levels and prevent heart attack and stroke. In addition, this medication may
decrease the risk of brain hemorrhage or bleeding in patients with CCM. This study will
examine whether the permeability of the BBB changes following the administration of
simvastatin for three months.
Phase:
Early Phase 1
Details
Lead Sponsor:
University of New Mexico
Collaborators:
National Institute of Neurological Disorders and Stroke (NINDS) University of California, San Francisco