The objective of this study is to perform a prospective, randomized controlled trial
investigating the clinical usage of perioperative dexamethasone usage on APR activation,
postoperative morphine usage, postoperative nausea, and hospital length of stay.
There will be a control control and a Dexamethasone cohort. Participants will be randomized
into one of the two cohorts. Patients in the control group will receive one 8mg dose of
dexamethasone intraoperatively as per standard of care anesthesia protocols. Patients
randomized to the dexamethasone cohort will be administered 8 mg of dexamethasone with 3
additional doses administered at 8-hour intervals following surgery for a total of 4 doses.
All study activities will tale place at Egleston during the patient's planned inpatient stay
for their posterior spinal fusion.
This project has the potential to validate the utility of dexamethasone as a way to optimize
postoperative care following PSF for AIS by minimizing the need for opioid medications and
enhancing mobility and recovery.