Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery
Status:
Recruiting
Trial end date:
2024-06-01
Target enrollment:
Participant gender:
Summary
PENGUIN is a pragmatic multi-center trial investigating the effects of pre-operative
mouthwash and perioperative oxygen on the incidences of pneumonia and surgical site infection
(SSI) following major abdominal surgery.
Patients will be recruited from low and middle income countries and randomly assigned to a
trial treatment arms: a) pre-operative chlorhexidine mouthwash and 80-100% FiO2; b) no
pre-operative mouthwash and 80-100% fraction of inspired oxygen (FiO2); c) pre-operative
chlorhexidine mouthwash and 21- 30% FiO2; or d) no pre-operative mouthwash and 21-30% FiO2.