Perioperative Pregabalin for Reducing Opioid Consumption After Cardiac Surgery
Status:
Recruiting
Trial end date:
2022-10-09
Target enrollment:
Participant gender:
Summary
OPIATE is a double-blinded randomized controlled trial (RCT) comparing pregabalin in addition
to usual care to usual care alone for reducing post-operative opioid consumption in patients
undergoing on-pump cardiac surgery. Patients will be randomized in a 1:1 ratio to receive
either pregabalin (300 mg pre-operatively + 75 mg post-operatively twice daily until
discharge or 5 days) in addition to usual care or matching placebos in addition to usual
care. The aim of the trial is to show that pregabalin is superior to usual care (i.e. a
superiority trial).