Perioperative Iron With Erythropoietin in Bilateral Total Knee Replacement Arthroplasty (TKRA)

• Status: Completed
• Trial end date: 2009-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

The object of this study is to evaluate whether low dose intravenous iron and erythropoietin (Epo) can decrease transfusion requirement after the bilateral TKRA.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Bundang Hospital
• Treatments: Epoetin Alfa; Ferric Compounds; Ferric Oxide, Saccharated; Iron

Criteria

Inclusion Criteria:

• Female patients undergoing bilateral total knee replacement arthroplasty

• American society of anesthesiologist class 1-3

• Hb>100 g/L

• Either serum ferritin<100 ng/ml or 100saturation (TSAT) <20%

Exclusion Criteria:

• Hematologic disease

• Thromboembolic disease

• Hepatic or renal disease

• Coagulation disorder

• Infection

• Malignancy

• Under anticoagulant therapy

• Hypersensitivity to iron sucrose or Epo

• Preoperative autologous blood donation

• Use of iron or Epo and blood transfusion within the previous 1 month