Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac Surgery

• Status: Not yet recruiting
• Trial end date: 2021-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Evaluation of the effect of peri-operative continuation of oral metformin therapy on the incidence of perioperative hyperglycemia compared to standard preoperative cessation of oral metformin therapy 24h before surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kepler University Hospital
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Age 18-99 years

• Diabetes Mellitus Typ 2

• Oral metformin therapy

• Non cardiac-surgery

• Informed consent

Exclusion Criteria:

• Insulin therapy

• Ambulatory surgery

• Preoperative therapy with glucocorticoids (prednisolon or equivalent ≥ 5mg/day for more than 7 days)

• Planned postoperative ICU-stay

• Advanced renal insufficiency (eGFR < 45ml/kg/min)

• Advanced liver cirrhosis or failure (Child-Pugh B or C)

• Alcohol abuse

• Pregnancy,

• Perioperative administration of contrast dye