The aim of this study is to assess if hypogonadic men with periodontitis benefit from
testosterone replacement therapy before being submitted to periodontal treatment. Fifty
hypogonadic men (Total Testosterone <200ng/dL) will be recruited from the Clinics Hospital at
Federal University of Paraná and subjected to periodontal evaluation by a trained and
calibrated researcher. The subjects presenting with periodontitis (assessed by clinical
parameters) will be randomly allocated to "testosterone replacement therapy" (TRT) group or
"placebo" for 3 months. After that time, all patients will receive nonsurgical periodontal
treatment, which will be reassessed after 45 days. Clinical parameters (such as probing
depth, gingival and plaque index, clinical attachment loss, bleeding on probing), sub
gingival plaque and gingival crevicular fluid will be collected at baseline, just before
therapy and 45 days after therapy.
Phase:
Phase 4
Details
Lead Sponsor:
Universidade Federal do Paraná
Collaborators:
Universidade de Guarulhos Universidade Estadual Paulista - UNESP