Perineuraxial Anesthesia Fluid Management and Infant Neurobehaviors
Status:
Completed
Trial end date:
2011-05-01
Target enrollment:
Participant gender:
Summary
Early change in neurobehavior is strongly associated with the intelligence development of
children. Previous studies reported that cesarean section itself could influence the later
development of children. In addition, neuraxial anesthesia including epidural, spinal and
combined spinal epidural anesthesia (CSEA) are the major forms used during cesarean delivery,
and these anesthesia techniques will undoubtedly evoke hypotension and corresponding
hemodynamic alteration, of which would result in decreasing in umbilical placental
insufficiency and fetus hypoxia leading to early abnormality of neurobehaviors in infants.
Fluid management, such as crystalloid and colloid, is the common ones given before or / and
after neuraxial anesthesia to prevent or reverse hypotension. However, it is still unknown
whether the perineuraxial anesthesia fluid resuscitation could improve the neurobehavior
scorings, and could produce positive effect on later intelligence development. Herein the
investigators hypothesized that effective perineuraxial anesthesia fluid management during
cesarean section would prevent the occurrence of hypotension and improve infant's
neurobehavior scorings.