Periarticular Penetration of Cefazolin and Clindamycin in Second Stage Revision Arthroplasty of the Hip
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
To prevent periprosthetic joint infection (PJI), optimal penetration of antibiotics into the
joint-space is needed. In revision arthroplasty, the incidence of PJI is increased compared
to primary arthroplasty. In this study, the penetration of antibiotic agents into the
synovial fluid and bone will be analyzed. The concentration of antibiotics will be related
tot the to the susceptibility (minimal inhibitory concentration; MIC-90) of microorganisms
that frequently cause PJI.