Peri-articular Tranexamic Acid Injection in Total Knee Arthroplasty

• Status: Completed
• Trial end date: 2013-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the peri-articular tranexamic acid injection in total knee arthroplasty which is an alternative route of administration for blood loss reduction. Half of participants will receive intravenous tranexamic acid injection, while the other half will receive peri-articular tranexamic acid injection during total knee arthroplasty.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Thammasat University
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

• adult patients with osteoarthritis in need of a TKA

Exclusion Criteria:

• inflammatory arthritis

• post-traumatic arthritis

• a history of or current venous thromboembolic disease

• any underlying disease of haemostasis

• cirrhosis

• chronic renal failure

• patients on anticoagulants or strong antiplatelet drugs (e.g. warfarin, clopidogrel)

• know allergy to TXA

• defective color vision

• preoperative hemoglobin <10 g/dL

• platelet count < 140,000 /uL3