Peri-articular Injection Utilizing a Pain Cocktail With and Without Exparel

• Status: Withdrawn
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: All

Summary

A prospective, randomized control study will be conducted to compare postoperative pain control in a series of patients treated with either:

1. a local cocktail.

2. a local cocktail plus Exparel.

3. marcaine plus Exparel prior to wound closure following knee arthroplasty.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Louisville
• Collaborator: Arthroplasty Foundation, Inc.
• Treatments: Bupivacaine; Clonidine; Epinephrine; Epinephryl borate; Ketorolac; Ketorolac Tromethamine; Racepinephrine; Ropivacaine

Criteria

Inclusion Criteria:

• Institutional Review Board (IRB) review has been conducted and approval of the study has been obtained

• The subject underwent a primary total knee replacement under adductor canal block with general anesthesia

Exclusion Criteria:

• The subject is a minor

• The subject is on chronic narcotics

• The subject has an indwelling pain pump

• The subject is having a knee revision surgery

• The subject is having a partial knee replacement

• The subject has a history of sepsis in a previously replaced joint

• The subject has back pain

• The subject has radicular pain

• The subject suffers from depression

• The subject has fibromyalgia

• The subject is currently involved in any personal injury litigation, medical-legal, or worker's compensation claims