Performance of Cimetidine-corrected MDRD Equation in Renal Transplant Patients
Status:
Completed
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
Among the different creatinine-based GFR predicting equations, the MDRD equation gives the
best prediction in renal transplantation but does not provide the level of accuracy usually
seen in renal patients with native kidneys.
Blocking the tubular secretion of creatinine with an oral administration of cimetidine is
likely to make creatinine a more accurate marker of GFR.
We will test the hypothesis that the accuracy of the MDRD equation will be improved in renal
transplant patients by incorporating into the equation a cimetidine-corrected serum
creatinine value.