PFCs (perfluorocarbons, PFC), an ideal liquid respiratory media, has special chemical and
biological properties, including high solubility of gas, swiftness of carrying and release,
low surface tension, high proportion, almost non-absorbing and non-metabolic characteristics
in the body. On the basis of the strong animal data suggesting the efficacy of PFC vapor
inhalation in models of lung injury, we performed a randomized clinical trial comparing PFC
vapor inhalation with conventional mechanical ventilation（CMV）in patients with Acute Lung
Injury/Acute Respiratory Distress Syndrome（ALI/ARDS）. The investigators will apply the
Invasive Mechanical Ventilation (IMV) to the vaporized perfluorocarbon inhalation,
objectively evaluate its curative effect on the acute respiratory distress syndrome, and
meanwhile assess the safety of PFC.
Phase:
Phase 2
Details
Lead Sponsor:
Chinese PLA General Hospital
Collaborators:
309th Hospital of Chinese People's Liberation Army Air Force General Hospital of the PLA Beijing Shijitan Hospital Beijing Shijitan Hospital, Capital Medical University First Hospitals affiliated to the China PLA General Hospital General Hospital of Chinese Armed Police Forces The 306 Hospital of People's Liberation Army The Second Artillery General Hospital