The purpose of the study is to investigate phenoxymethylpenicillin (the v-penicillin) and
trimethoprim's possible induction of oxidative stress in human cells. The induction is
examined by comparing changes in oxidative stress in the treatment group with the change in a
placebo group. The study is a randomized-based placebo-controlled study. Each treatment group
consists of 30 healthy male volunteers who consume either v-penicillins, trimethoprim or
placebo over 7 days. The induction of oxidative stress is measured by 8-oxoguanosine and
8-oxodeoxoguanosine, isolated from urine. A t-test will be performed to compare drug
treatment with placebo. The results will be published.
Phase:
Phase 1
Details
Lead Sponsor:
Henrik Enghusen Poulsen
Collaborators:
Klinisk Biokemisk Afdeling Klinisk farmakologisk Afdeling Sektion for Biomedicin Institut for Veterinær Patobiologi