Pentoxifylline for Acute Alcoholic Hepatitis (AAH)

• Status: Terminated
• Trial end date: 2006-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to demonstrate the effectiveness of pentoxifylline compared to placebo in AAH while studying putative mechanisms that are plausible and testable. The main hypothesis is that pentoxifylline reduces the 90-day mortality of AAH.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Wisconsin, Madison
• Treatments: Pentoxifylline

Criteria

Inclusion Criteria:

• Inpatient with acute alcoholic hepatitis

• Model for End-Stage Liver Disease (MELD) of 15 or greater

• Recent alcohol abuse

Exclusion Criteria:

• Recent infection

• Other life threatening disease

• Severe coagulopathy

• Another non-alcoholic cause of liver disease