Pentoxifylline as Adjunctive Therapy in Patients With Ulcerative Colitis
Status:
Not yet recruiting
Trial end date:
2025-02-20
Target enrollment:
Participant gender:
Summary
The exact underlying mechanisms of ulcerative colitis (UC), an idiopathic, chronic
inflammatory disease marked by diffused inflammation of the colon and rectum mucosa, are
still unknown. Due to genetic, immune, and environmental factors, UC is highly dependent on
cellular immune reactions and exaggerated inflammatory responses. The release of several
cytokines, kinins, leukotrienes, platelet-activating factor (PAF), and reactive oxygen
species is connected to immunological activity (ROS). Additionally, many of the cytokines
will start an acute phase response, making the inflammation worse.