Pentoxifylline Effect in Patients With Diabetic Nephropathy.(PENFOSIDINE STUDY)
Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
One of the purposes of the management of the patient with chronic kidney disease (CKD)is to
slow the decline of renal function. The mechanisms by which the renal function declines
involve inflammatory and fibrotic responses due in part by the effects of oxidative stress.
Pentoxifylline (PTX)is a drug that stimulates adenosine receptors, and produces inhibition of
phosphodiesterases, as well as being a dopaminergic modulator through D1 and D2 receptors.
Its main effects are inhibition of the inflammatory state by decreasing serum levels of tumor
necrosis factor alpha (TNF-ɒ) and monocyte chemo attractant protein 1 (MCP_1), which may slow
down the decline of renal function. It also produces diminish of sympathetic activity, with
the reduction of circulating levels of norepinephrine (NA), which may contribute to the
reduction of glomerulosclerosis in diabetic patients. In the connective tissue increases the
activity of the collagenases and decrease of collagen, fibronectin and glucosamine of the
fibroblasts as well as inhibition of oxygen free radicals. Due to its antioxidant,
anti-inflammatory and anti-fibrotic effects, PTX can result in an excellent therapeutic
option for the prevention of CKD in DM2.
This work proposes the use of pentoxifylline as treatment CKD in DM2. Its application in
patients with CKD will allow a therapeutic management with different targets, for its
antioxidant, anti-inflammatory and antifibrotic effects that will be evaluated by means of
fibrosis, inflammation and oxidative stress markers. The results will be of great importance
in clinical practice, since they will justify the use of a new pharmacological tool, already
known, with minimal adverse effects and low cost, accessible to all strata of the population
since it is found as generic.
Phase:
Phase 4
Details
Lead Sponsor:
Maria Eugenia Galván Plata
Collaborators:
Centro de Investigación Biomédica de Michoacán. Coordinación Auxiliar Medica de Investigación en Salud. Delegación Michoacán. Hospital General de Zona N° 83 Instituto Mexicano del Seguro Social. Hospital General Regional N° 1 Instituto Mexicano del Seguro Social.