Penicillamine Chelation for Children With Lead Poisoning
Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Childhood Lead Poisoning is a widespread disease that has few effective treatments. The
specific aims of this proposed clinical trial are threefold:
- To determine whether a six-week course of a newly formulated d-penicillamine suspension
will effectively reduce blood lead level in children aged 6 months to 16 years with
blood lead levels of 15-25 μg/dL.
- To determine whether d-penicillamine chelation produces a sustained reduction in blood
lead level in comparison with succimer and other lead chelators which always produce a
significant post-treatment "rebound".
- To determine whether chelation with d-penicillamine improves the physiologic
disturbances that can be measured in children with blood lead levels in this range.