Penehyclidine for Prevention of Nausea and Vomiting After Bimaxillary Surgery
Status:
Completed
Trial end date:
2021-04-15
Target enrollment:
Participant gender:
Summary
Postoperative nausea and vomiting (PONV) is a common complication after surgery. Patients
undergoing orthognathic surgery are reported to have a high rate of PONV, especially those
undergoing bimaxillary surgery. Activation of cholinergic system plays an important role in
the development of PONV. Penehyclidine is an muscarinic antagonists which selectively block
M1 and M3 receptors and is commonly used to decrease oral secretion. The investigators
hypothesize that continuously administrated penehyclidine during perioperative period can
reduce the incidence of PONV in patients undergoing bimaxillary surgery.