The purpose of this study is to test the safety and tolerability of pemetrexed administered
to people with chordoma. Other purposes of this study are to:
- find out side effects (good and bad) of pemetrexed;
- learn more about how pemetrexed might affect the growth of cancer cells;
- evaluate tumor characteristics by collecting tumor tissue samples if available;
- look at biomarkers (biochemical features that can be used to measure the progress of
disease or the effects of a drug) in blood and cerebrospinal fluid if available.