Overview

Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65)

Status:
Not yet recruiting
Trial end date:
2027-08-31
Target enrollment:
0
Participant gender:
Female
Summary
The primary objective is to compare pembrolizumab plus paclitaxel with or without bevacizumab to placebo plus paclitaxel with or without bevacizumab, with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by the investigator. The hypotheses are that pembrolizumab plus paclitaxel with or without bevacizumab is superior to placebo plus paclitaxel with or without bevacizumab, with respect to PFS per RECIST 1.1 as assessed by the investigator for participants with programmed cell death ligand 1 (PD-L1) positive tumors (Combined Positive Score [CPS] ≥1) and that pembrolizumab plus paclitaxel with or without bevacizumab is superior to placebo plus paclitaxel with or without bevacizumab, with respect to PFS per RECIST 1.1 as assessed by the investigator for all participants.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Merck Sharp & Dohme Corp.
Treatments:
Bevacizumab
Docetaxel
Paclitaxel
Pembrolizumab
Criteria
Inclusion Criteria:

- Has histologically confirmed epithelial ovarian, fallopian tube, or primary peritoneal
carcinoma.

- Has received 1 or 2 prior lines of systemic therapy for ovarian cancer (OC), including
at least 1 prior platinum-based therapy. Participants may have received a prior poly
(ADP-ribose) polymerase inhibitor (PARPi), anti-PD-1/anti-PD-L1 therapy or
bevacizumab; these will not be considered a separate line of therapy. Any chemotherapy
regimen change due to toxicity in the absence of disease progression will be
considered part of the same line of therapy.

- Has provided documented informed consent for the study.

- Has radiographic evidence of disease progression within 6 months (180 days) after the
last dose of platinum-based chemotherapy for OC (i.e., platinum-resistant disease).

- Is a candidate for paclitaxel chemotherapy (and bevacizumab, if using).

- Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 assessed
within 3 days before randomization.

- For a female participant, she is not pregnant or breastfeeding, and at least one of
the following conditions applies: Is not a woman of childbearing potential (WOCBP) OR
Is a WOCBP and uses a contraceptive method that is highly effective (with a failure
rate of <1% per year).

- Has radiographically evaluable disease, either measurable or nonmeasurable per RECIST
1.1, as assessed by the local site investigator.

- Archival tumor tissue sample or newly obtained core or incisional/excisional biopsy of
a tumor lesion not previously irradiated has been provided.

- Have adequate organ function.

Exclusion Criteria:

- Has nonepithelial cancers, borderline tumors, mucinous, seromucinous that is
predominantly mucinous, malignant Brenner's tumor and undifferentiated carcinoma.

- Has primary platinum-refractory disease, defined as disease that has progressed per
RECIST 1.1 while receiving first-line platinum-based therapy.

- Has prior disease progression on weekly paclitaxel alone.

- Has uncontrolled hypertension.

- Has current, clinically relevant bowel obstruction including related to underlying
epithelial OC, abdominal fistula or gastrointestinal perforation, intra-abdominal
abscess, or evidence of rectosigmoid involvement by pelvic exam.

- Has a history of thrombotic disorders, hemorrhage, hemoptysis, or active
gastrointestinal bleeding within 6 months before randomization.

- Has received >2 prior lines of systemic therapy for OC.

- Has received prior systemic anticancer therapy including investigational agents within
4 weeks before randomization.

- Has received prior radiation therapy within 2 weeks of start of study intervention.

- Has not recovered adequately from surgery and/or any complications from the surgery.

- Has received colony-stimulating factors (e.g., granulocyte colony-stimulating factor
[G-CSF], granulocyte-macrophage colony-stimulating factor,[GM-CSF] or recombinant
erythropoietin) within 4 weeks before randomization.

- Has received a live or live-attenuated vaccine within 30 days before the first dose of
study intervention.

- Is currently participating in or has participated in a study of an investigational
agent or has used an investigational device within 4 weeks before the first dose of
study intervention.

- Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy.

- Has a known additional malignancy that is progressing or has required active treatment
within the past 3 years.

- Has known active central nervous system (CNS) metastases and/or carcinomatous
meningitis.

- Has severe hypersensitivity (≥Grade 3) to pembrolizumab, paclitaxel, or bevacizumab
(if using) and/or any of their excipients.

- Has an active autoimmune disease that has required systemic treatment in the past 2
years.

- Has a history of (noninfectious) pneumonitis/interstitial lung disease that required
steroids or has current pneumonitis/interstitial lung disease.

- Has an active infection requiring systemic therapy.

- Has a known history of human immunodeficiency virus (HIV) infection.

- Has a known history of Hepatitis B or known active Hepatitis C virus infection.

- Has a history or current evidence of any condition, therapy, laboratory abnormality,
or other circumstance that might confound the results of the study.

- Has a known psychiatric or substance abuse disorder that would interfere with the
participant's ability to cooperate with the requirements of the study.

- Participant, in the judgement of the investigator, is unlikely to comply with the
study procedures, restrictions, and requirements of the study.

- Has had an allogenic tissue/solid organ transplant.