Patients With Chronic Obstructive Pulmonary Disease at Altitude - Effect of Nocturnal Oxygen on Breathing and Sleep

• Status: Completed
• Trial end date: 2014-10-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the effect of nocturnal oxygen therapy during a stay at moderate altitude on breathing and sleep of patients with chronic obstructive lung disease.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Zurich

Criteria

Inclusion Criteria:

• chronic obstructive pulmonary disease (COPD), GOLD grade 2-3

• residents at low altitude (<800 m)

Exclusion Criteria:

• unstable condition, COPD exacerbation

• mild (GOLD 1) or very severe COPD (GOLD 4)

• requirement for oxygen therapy at low altitude residence

• hypoventilation

• pulmonary hypertension

• more than mild or unstable cardiovascular disease

• use of drugs that affect respiratory center drive

• internal, neurologic or psychiatric disease that interfere with protocol compliance including current heavy smoking (>20 cigarettes per day), inability to perform 6 min walk test.

• previous intolerance to moderate altitude (<2600m).

• exposure to altitudes >1500m for >2 days within the last 4 weeks before the study.

• pregnant or nursing patients