Patient Tolerability and Efficacy of Bowel Preparation With Split Dose Picosalax vs. Split Dose PEG
Status:
Terminated
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
Introduction: Colonoscopy is an important tool for colon cancer screening. Proper colon
cleansing is essential to ensure adequate mucosal examination. Timing of bowel preparation
administration is now recognized as an important component for achieving superior cleansing.
Multiple randomized controlled trials and meta-analyses have found split-dosing to be
superior than day-before dosing. Objective: This study aims to compare two types of bowel
preparations in split-doses to assess for differences in patient tolerability, as well as
efficacy of colon cleansing. Methods: This is a prospective, single-blinded,
randomized-controlled trial. Patients who are being referred for a colonoscopy will be
recruited to participate in the study. They will be randomly assigned to receive either a
split-dose polyethylene glycol (PEG) or picosalax (P/MC) bowel preparation. Patient
tolerability will be examined through questionnaires. The endoscopist performing the
colonoscopy will use two standardized bowel preparation scoring systems to evaluate the
quality of the cleansing. The investigators propose that P/MC will be superior to PEG in
patient tolerability and non-inferior in bowel cleansing effects.