Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG
Status:
Completed
Trial end date:
2015-06-01
Target enrollment:
Participant gender:
Summary
Objective: The objective of this pilot study is to characterize the cardiac uptake patterns
of I-123 mIBG in stress-induced (Takotsubo's) cardiomyopathy.
Hypothesis: Perturbations in sympathetic innervation are the underlying pathogenesis of
stress induced cardiomyopathy and will result in abnormalities in I-123 mIBG cardiac imaging.
Thus, planar and SPECT I-123 MIBG imaging will provide insight into the pathogenesis of
stress-induced cardiomyopathy, and may lead to the development of more specific diagnostic
criteria.
Study design: This proposal is for a prospective pilot study to characterize perturbations in
cardiac sympathetic innervation in patients with stress induced cardiomyopathy by performing
planar and SPECT I-123 MIBG imaging during the acute presentation and after recovery of LV
function.