Paradoxical Excitement Response During Sedation Between Dexmedetomidine and Propofol in Hazardous Alcohol Drinker

• Status: Unknown status
• Trial end date: 2019-05-31
• Target enrollment: 0
• Participant gender: All

Summary

1. Adequate sedation with classical sedative agents, propofol

2. Sedation with propofol may induce paradoxical excitement response in heavy alcohol drinkers

3. Dexmedetomidine, α2 receptor agonist, may provide adequate sedation in heavy alcohol drinkers

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chonnam National University Hospital
• Treatments: Dexmedetomidine; Ethanol; Propofol

Criteria

Inclusion Criteria:

• 19~65 yr-old patients who is scheduled to undergo knee surgery with regional anesthesia

Exclusion Criteria:

• History of taking anxiolytics, hypnotics, antiepileptic drugs

• Abnormal liver function test (eg: Liver cirrhosis, elevated liver enzymes)

• History of allergic reaction with dexmedetomidine or propofol

• Contraindication with regional anesthesia

• American society of anesthesiologist Physical status III or IV